مطالعه نقش ترمیمی PRP در آسیب‌شناسی نحوه توزیع سلولی، جمعیت سلولی زنده و رنگ‌پذیری ماتریکس غضروف مفصلی استخوان ران ناشی از استئوارتریت

    Purpose : Osteoarthritis is common in elderly people of the world, which is due to cartilage destruction and osteophyte formation in the joint and which induce chronic pain and disability. The PRP due to its high level of growth factors can help the repair process of the diseased joints. In this study the autogenous PRP have been used for treatment of experimentally induced osteoarthritis in the rabbits.   Material and Methods : Osteoarthritis was induced in the rabbits left knee by resection of the anterior cruciate ligament under general anesthesia. Eight weeks post operation and development of osteoarthritis signs, 0.5 ml PRP was injected into the diseased joint in the rabbits of the test group. The control group did not receive any treatment. The rabbits were euthanized and histopathologic samples were collected at 8, 12 and 16 weeks post operation.   Results : The histopathologic study in the control group showed least live cells, worst cellular arrangements and least articular cartilage stainable matrix showing advanced osteoarthritis. But in the group received the PRP there was no sign of osteoarthritis.   Conclusion : The authogenous PRP due to its high level of growth factors is an effective source for treatment of osteoarthritis.     SOURCE: URMIA MED J 2014: 25(3): 257 ISSN: 1027-3727